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Dr. Davey Smith, Head of Infectious Diseases and Global Public Health at UCSD, says it’s possible we could need COVID vaccines and boosters for the rest of our lives as new variants keep emerging.

A Hispanic family lived their worst nightmare during the pandemic when their twin children fell ill and only one of them survived.

A North County brewery whose name has religious overtones has faith in its new brewery outpost down near Petco Park.

Michael Spitz, 35, was seriously hurt a little before 5:30 p.m. on Sunday at the Sentinel Rock Formation in Joshua Tree National Park

Patrick Mitchell’s number one goal in life was to live to be 100 years old, but that one wish abruptly came to an end about a year ago. At age 72, Patrick was diagnosed with terminal stage 4 pancreatic cancer.

Old school college recruiting versus new school recruiting: San Diego State head football coach Brady Hoke shared a funny story when comparing the two.

Police are seeking the public’s help in finding the suspect in a murder that occurred near Sunset Cliffs last summer.

While San Diego County businesses deal with an employee shortage, some local nonprofits are dealing with a shortage of volunteers.

The deaths of Raquel Wilkins and her 2-year-old son, Denzel Browning-Wilkins, were deemed suspicious at the time.

After more than a half-century in law enforcement, including 12 years as San Diego County’s Sheriff, Bill Gore announced he is retiring next month.

The county board of supervisors redistricting process takes place every 10 years.

San Diego Museum Month will return with in-person events in February, and half-off admission at more than 45 local museums and other cultural attractions, the San Diego Museum Council announced Tuesday.

Members of the San Diego High School track team say more tests in hand could be a win-win for families on and off the field.

New artificial reef balls will kick-start a natural oyster reef that will filter water and protect the bay’s eelgrass, the nursery of juvenile fish.

At least three cities in San Diego County are mandating COVID-19 vaccines for all municipal workers.

Orangutan infant Kaja was born less than two weeks following his father’s death at the San Diego Zoo

The state delivered almost 2 million N95 masks to the San Diego County Office of Education, which is overseeing distribution to school districts. Another 6 million masks are expected in future shipments, which should include masks for small children.

A man allegedly caught with a half-dozen Molotov cocktails and suspected bomb-making materials in his car on a northern San Diego County roadside was behind bars Tuesday on a slate of explosives-related charges.

Weddle, the 37-year-old former San Diego Charger fan favorite who still lives in San Diego, came out of retirement last week to help an injury-depleted Los Angeles Rams team.

The painting, now worth more than $30 million, was traded in 1939 by a Jewish couple to a Nazi art appraiser for a small amount of cash and visas to escape Germany

A Poway man accused of punching two medical assistants at a coronavirus vaccine clinic in Tustin, California, last month, and groping a nurse after his arrest, has been formally charged, the Orange County District Attorney’s Office announced Tuesday.

The man had already been kicked out of the Seven Mile Casino on Monday prior to returning and scuffling with security, according to Chula Vista police

Some Chula Vista residents will now be able to report overflowing trash to request clean-up services, the city announced on Tuesday.

The deadline has approached for San Diego State University student-athletes and on-campus students to get their COVID-19 booster shots in order to attend in-person instruction.

A news photographer was killed in the Mexican border city of Tijuana on Monday, the same day press groups said a reporter had been killed in the Gulf coast state of Veracruz last week.

The characteristics of the Omicron variant have some people thinking no matter what they do getting the virus is inevitable.

Councilmembers say they’re working with the city manager and attorney to find out what type of compensation they can get for Republic Services customers who were without trash service for a month.

San Diego can expect to see some lingering scattered showers Tuesday morning before skies clear up to a warm-up due to a Santa Ana wind pattern later this week.

San Diegans honored the life and legacy of Martin Luther King Jr. in many different ways on Monday – some explored a virtual outdoor exhibit in Broadway Heights.

As soon as students head back to school after winter break, they head right back to their sport. But what if they had Covid? San Diego Unified School District is requiring more testing for all athletes, whether vaccinated or not. If a sport is in season, athletes get tested twice a week. For those out of season sports, like track…

Nurses, exhausted from working through the latest COVID-19 surge, say they haven’t been paid overtime or bonus money because of a ransomware attack that hit Scripps Health’s payroll vendor.

A giraffe calf born Monday at the San Diego Zoo Safari Park was the perfect gift to the late actress and wildlife advocate, Betty White, on what would have been her 100th birthday.

A “squatter” took up residence in a hospitalized man’s home after seeing his tragedy on the news. He changed the locks and the utility bills, and stayed in the home for more than a week before he was arrested.

Serena Stevens, who was reported missing on Monday, has been found, authorities said.

Many of us have multiple devices. Our cellphones, laptops, tablets, TVs all get upgraded from time to time and we have to decide what to do with our old stuff. Consumer Reports says the saying one person’s trash is another’s treasure might apply to your old electronics.

A memorial honoring the 11 U.S. Marines and two other service members killed in the terrorist bombing at Kabul Airport in Afghanistan last August will be unveiled Saturday at a ceremony in the Riverside County community of Norco.

Sanitation workers’ weeks-long strike will come to an end in the South Bay and San Diego after the union representing them agreed on Monday to the terms Republic Services proposed in what the service described as its “last, best, and final” offer.

San Diego County’s Department of Environmental Health and Quality Monday extended the existing water contact closure area at the Tijuana Slough shoreline north to include the Imperial Beach shoreline.

A man died in an solo accident when he hit a center median, flipping his car near the Paseo Ranchero intersection, Chula Vista police said Monday.

San Diego City Councilman Chris Cate has partnered with local community organizations to open a new COVID-19 testing site at Zion Market on Clairemont Mesa Boulevard at 9 a.m. Monday.

The website which was announced on Jan.14 will be the place where Americans can request free at-home COVID-19 tests. “I know from experience that it’s difficult to ramp us testing quickly, it takes a lot of infrastructure it takes a lot of personnel when you are trying to respond to a surge that can be very difficult,” San Diego...

A 22-year-old woman was fatally wounded during a stabbing attack Sunday morning at a park in the Sabre Springs community of San Diego, authorities said.

The Martin Luther King Jr. holiday on Monday marks the 25th anniversary of the day of service that celebrates the Civil Rights leader’s life and legacy.

A band of light rain due was slowly moving north and covered most of western San Diego County, with most areas receiving a few hundredths of an inch of precipitation on Saturday.

More and more parents are testing their children for coronavirus at home, whether schools handed them at-home testing kits or if it’s because they want to visit other family members.

The National Tsunami Warning Center has canceled the tsunami advisory for San Diego County beaches after an undersea volcano erupted near the Pacific nation of Tonga on Saturday.

Before the end of the month, the San Diego County Board of Supervisors will vote on an ordinance that will allow people to sell meals prepared in their home kitchens

A suspect in the slaying of a man who was shot and dragged by a car in a Mount Hope-area neighborhood seven months ago was behind bars Friday following his arrest in Baja California.

When you go to the dog park, you’re guaranteed to see a few things: dogs, of course, their owners, maybe a few tennis balls, and you always need to watch where you step.

Over the past seven days, nearly 29% of COVID-19 tests reported in San Diego County have come back positive, but positivity rates have stretched to nearly 32% in La Mesa and La Presa.

The San Diego Unified School District is giving parents a heads-up: Some schools could close for a day or longer if the current staffing shortage gets worse.

A record 76,792 candidates applied to San Diego State University for fall 2022, a number which university leaders say bodes well for the institution following several tumultuous years in the COVID-19 pandemic, it was announced Friday.

Chula Vista City Council will hold a special meeting Friday to enact a local state of emergency as trash accumulates throughout the city due to stalled contract negotiations between sanitation workers and their garbage collection company.

The in-custody death of a 38-year-old Mexican national who was arrested by federal officers at the U.S.-Mexico border in Otay Mesa after allegedly sneaking into the United States was under investigation Thursday.

The man who pleaded guilty to opening fire at a Hillcrest restaurant while employees and diners were inside was sentenced on Friday to 49 years in prison.

A man who allegedly fired off a gun as protesters demonstrated last summer outside San Diego Mayor Todd Gloria’s home pleaded not guilty Thursday to a felony count of negligently discharging a gun.

A Carlsbad man was jailed Thursday on suspicion of pointing a gun at another driver during a rolling road-rage confrontation on Interstate 5 in Solana Beach.

Outpatient treatments for people with COVID-19 are now available and on the shelves of several San Diego County pharmacies.

Short staff, rude customers – the list goes on for retail workers trying to work through yet another COVID-19 surge.

The Poway mayor and councilmembers unveiled a new affordable housing complex designed for seniors and veterans on Thursday.

The American Red Cross on Tuesday said it declared its first-ever “blood crisis” as it faces the worst national blood shortage in about a decade.

The city of Chula Vista is set to declare a public health emergency next week as trash piles up around the city. It comes as people are receiving bills for trash pickup, even though they say their trash and recycling is piling up.

Help from Governor Gavin Newsom is here for school districts struggling to stay open during severe staffing shortages.

For half a decade the Padres were touted as having one of the very best minor league systems in all of baseball. Then they dipped deep into it in trades for established big league players (the results of which have, so far, been mixed at best). In 2021 their system couldn’t overcome a lack of depth in the starting rotation…

Many businesses are having to close down early or pivot their hours because of staffing challenges brought on by the omicron variant. Some restaurants are even having to temporarily close down because of it and fear the closure could be permanent.

San Diego Zoo, Midway Museum get $10 million; Belly Up and Old Globe awarded $8 million

The San Diego Police Department has identified the man who was shot and killed by officers Monday after he was suspected of robbing a liquor store.

NBC 7’s Dagmar Midcap takes a look at some of the interesting facts and numbers from the recently released International Rhino Federation “State of the Rhino” report about the last decade of conservation efforts.

The San Diego County District Attorney’s Office warned residents Thursday to avoid buying unapproved at-home COVID-19 tests amid the recent surge of the Omicron variant.

SDFD says the person is in some sort of vertical tunnel but they’re not sure where, exactly.

A baby had stopped breathing at a home in the foothills of Vista but San Diego sheriff’s deputy Eli Woienski was there to help.

Landon Donovan lead the team to a 6-5-5 record during a COVID-19-condensed season.

It’s a New Year, meaning the San Diego City Council just elected its new president. District 9’s City Councilmember Sean Elo-Rivera was elected in an 8-1 vote. Here, you can get to know him a little better.

Fans of Sanrio’s cutesy characters can rejoice since the Hello Kitty Cafe Truck is rolling into San Diego County.

San Diego County reported 81 new influenza cases last week, a decline of 40% from the previous week’s 137 cases, the county Health and Human Services Agency announced Wednesday.

Just two months ago long lines at vaccination sites for kids were a common sight, but the numbers have slowed down since.

Did you feel that? Two small earthquakes were reported in Southeastern Riverside County Wednesday night, according to the U.S. Geological Survey. The shaking was felt in San Diego.

The Chula Vista City Manager will be declaring a Public Health Emergency and invoking the self-help clause on their contract with Republic Services, said councilmember Jill Galvez in a statement Wednesday.

Todd Gloria is giving his 2022 State of the City Address Wednesday night.

A new California state law is expected to help put more meals on the tables of hungry San Diegans.

NBC 7 takes a deep dive into the case, in the case of missing Chula Vista mother May “Maya” Millete on the new podcast series “Vanished: The Maya Millete Story.”