The Giants are 2 1/2 games back in the standings. San Francisco can take over first place in the NL West by sweeping the three-game series at home beginning Friday.
Padres have won seven of eight head-to-head meetings between the teams this season. The Giants are a very different team than the one that last played the Padres in May.
The biggest difference is the presence in the lineup of rookie Buster Posey, who is hitting .335 since being called up from the minors May 29, and Burrell, who has 10 homers in 154 at-bats since joining the Giants on June 4.
In post-game interviews Thursday, Jon Garland said the team is ready.
“I think it will put more pressure on him to pitch well,” Padres closer Heath Bell told the sports site.