Police said the three men took unspecified items from an Imperial Beach home.
After police located their green Hyundai sedan, the suspects refused to stop and led police on a 2-mile chase at speeds of over 65 miles per hour.
The Hyundai was traveling north on Silver Strand Boulevard when the driver attempted a U-Turn and hit a pickup truck.
Lt. Ken Stewart of the San Diego Police Department said one suspect was arrested in the car, and another nearby. The third suspect, who suffered fled, however, climbed a fence and ran into the Naval Amphibious Base, where was trapped in a building. The man gave up just as canine units, arrived, and he was arrested a little after 1 p.m.
Coronado fire officials said the two suspects arrested in or near the car were hospitalized with major trauma, as was the woman driving the pickup truck. Another woman was taken to the hospital with minor injuries.
Police said a flat-screen TV and other household items were found inside the Hyundai.