Oprah's Biggest Moments

Talk show queen Oprah Winfrey has signed off for good. Among the top “Oprah” moments from the past 25 years: Tom Cruise bouncing on Winfrey’s couch to proclaim his love for Katie Holmes in 2005. Check out more surprises, scandals and milestones in Oprah's career.

Image 1 of 30 Harpo Productions
    • cruisejumping2.jpg
    • oprah and tom cruise-7221.jpg
    • color purple cropped.jpg
    • 040511 oprah wagon fat.jpg
    • oprah liz taylor.jpg
    • 040511 oprah michael jackson 1993.jpg
    • 040511 oprah mad cow.jpg
    • 040511 mary tyler moore.jpg
    • Dr Phil cropped.jpg
    • 040511 oprah book club.jpg
    • 040511 oprah jonathan franzen.jpg
    • 040511 oprah james frey.jpg
    • oprah and dr oz.jpg
    • Orachael ray.jpg
    • 040511 Mattie Stepanek.jpg
    • 040511 oprah sidney poitier.jpg
    • oprah tina turner.jpg
    • 040511 oprah magazine.jpg
    • 040511 oprah car giveaway.jpg
    • oprah school africa ribbon.jpg
    • secret life of bees cropped.jpg
    • suze cropped.jpg
    • mphillips.jpg
    • kfc cropped.jpg
    • 041211 oprah precious.jpg
    • hugh jackman cropped.jpg
    • 040511 oprah lady gaga.jpg
    • bush cropped.jpg
    • Oprah and Best Friend Gayle.jpg
    • 040511 oprah own network.jpg

Please wait. Your gallery will be ready in 5 seconds.

Leave Comments
Don't Miss

local

2 hours ago

New Red-Light Sensors Installed in Poway

Drivers in Poway will be monitored by new devices designed to catch...

local

2 hours ago

Suspect Tries to Hide on Roof

You can run but you can’t hide from La Mesa police, even if you climb onto the

as-seen-on

May 22, 2013

Residents Rally to Clean Up after Tornado

NBC 7's Greg Bledsoe reports from Moore, Okla. on cleanup efforts...

shows

2 minutes ago

Watch NBC 7 Midday News

NBC 7 San Diego offers a live web version of NBC 7 San Diego Midday News.