A 22-year-old man has been taken to the hospital after after he was shot in the head in the 5500 block of Clairemont Mesa Blvd. in Clairemont, according to San Diego police.
Officers initially responded to a 911 call from the Pleasant Inn. The caller was in the room when the victim was shot around 7:13 p.m, according to officers.
A woman has been detained, and police are looking for a possible third person.
"We're just trying to sort out whether or not there were any other parties involved. One of the people who summoned us was one of the parties in the room," an officer told NBC 7. "We just trying to kind of put the pieces together and figure out what roles people played."
Guests of the motel say police didn't allow them to leave for several hours while they were doing interviews.
"I don't want to take my granddaughters back in there and stay the night," guest Aretha Valentin said. "I am seriously considered going to get our things and packing up and heading out, at least finding out somewhere else to stay."
The man is expected to survive, but his injuries are serious.
San Diego police are investigating.
No other information was available.
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