A woman in her 30s and a man in his 40s were killed after the woman sped a stolen motorcycle into a wall on the eastbound SR-54 connector from Interstate 5.
They were thrown from the motorcycle onto southbound I-5 below, California Highway Patrol (CHP) confirmed.
Several lanes were closed on I-5 as well as the eastbound 54 connector, but all lanes have now reopened, Caltrans confirmed.
The CHP said they were driving up to 100 miles an hour on the ramp.