Federal agents raided three pot dispensaries in San Diego acting on a "landlord law" that was put into action by the U.S. Attorney's office last year.
Landlords who rent to pot shops were warned to evict their tenants or face prosecution and lose their property.
Agents targeted "Golden West Collective" on University Avenue in North Park Wednesday with assistance from San Diego Police.
Trash bags filled with marijuana were brought out and at least one person was arrested.
"This is just the beginning for us, we're going to be going out and this thing is going to be ongoing for awhile," said Special Agent Amy Roderick.
Medicinal marijuana supporters protested outside the building chanting "Shame on you!" at the agents who were also helped by members of the San Diego County Sheriff's Department.
"We now have to buy our drugs from criminals," said pot supporter Rich Reil.
The property manager said the landlord has tried repeatedly to evict the owners of "Golden West" but they wouldn't leave the building.
It's unclear if the landlord will face any charges.
A sheriff's deputy told NBCSanDiego that two unmarked vehicles were also vandalized during the raid and investigators believe the protesters are responsible for the crime.