A 35-year-old male driver sustained major injuries, including burns to his face, after crashing his Lamborghini on northbound Interstate 15.
According to CHP officials, the crash happened around 11:20 p.m. Saturday just north of Mission Road.
Officials said a suspected DUI driver from San Marcos was driving at speeds of more than 100 mph when he traveled from a lane into the center median on the freeway.
The collision caused the vehicle to split in half and the car quickly caught on fire.
The driver sustained major injuries and burns and was airlifted to UCSD hospital.
CHP officials said both the northbound and southbound lanes on I-15 were closed down for 20 minutes as the air ambulance landed.
No other vehicles were involved and nobody else was hurt.
The investigation is ongoing and officials believe alcohol may have played a role in the fiery crash.