A crash involving a tractor trailer blocked traffic in both directions along State Route 94 in Dulzura for much of Friday, according to the California Highway Patrol.
The CHP says just before 10:30 a.m., a 22-year-old man was driving a tractor trailer west on SR-94.
According to officers, the driver took a curve in the road at an unsafe speed, causing the load on the trailer to shift near Community Building Road.
The truck overturned directly into the path of a 2010 Chevy Silverado heading the opposite direction.
The trailer partially crushed the pickup truck's roof, and several people inside the Chevy were taken to Sharp Memorial Hospital with major injuries.
The driver of the tractor trailer was not injured.
A Sig Alert was issued for SR-94 at Marron Valley Road while officials shut down the road so they could remove the trailer.
No other vehicles were involved, and neither drugs nor alcohol were a factor, the CHP says.