Doug O'Neill was all smiles after early 3-1 favorite Nyquist drew the No. 13 post for the 142nd Kentucky Derby.
The number with an unlucky reputation didn't faze the trainer. In fact, it brought back good memories.
Nyquist left from the same spot when he won the Breeders' Cup Juvenile last year at Keeneland, part of his 7-0 career record.
The Powerball jackpot has grown even larger.
There was no jackpot winner in Wednesday night's drawing, increasing the prize from $348 million to an estimated $415 million.
While that's not chump change, it's a far cry from the $1.6 billion Powerball prize shared by three winning lottery ticketholders in January, the largest ever jackpot draw in the world. No one has won the full jackpot since March 2.
Powerball says the odds of winning the top prize are one in more than 292 million.
Ohio Gov. John Kasich, the last of Donald Trump's rivals for the Republican nomination, suspended his presidential campaign Wednesday.
"The Lord has a purpose for me as he has for everyone, and as I suspend my campaign today, I have renewed faith, deeper faith, that the Lord will show me the way forward and fulfill the purpose of my life," Kasich said in Columbus.
Kasich, 63, launched his campaign last summer, the 16th Republican to join the field.
A jury found Steven Briel guilty of first-degree murder, strangulation and abduction in the death of a University of Mary Washington student last year.
Grace Mann, 20, was killed April 17, 2015, at the Fredericksburg, Virginia, home she shared with Briel and two other roommates.
The jury has recommended Briel be sentenced to life in prison with an additional 11 years.
Much of the courtroom was in tears during the verdict and jurors passed tissues to one another.
Tractor trailers, many emblazoned with soda name brands on their sides, surrounded Philadelphia City Hall two hours before a public hearing Wednesday evening on Mayor Jim Kenney's proposed "soda tax."
The drivers were joined by other groups who objected to the tax, including corner store coalitions and beverage distributors, which rely on soda and other sugary drinks for revenue.
Most of the organizations and businesses against Kenney's proposed 3-cents-per-ounce tax on sugary drinks are part of an umbrella group called Philadelphians Against the Grocery Tax Coalition.
A New Hampshire business owner says vehicles outside are covered in human ashes because of a crematorium next door.
Doug Frederick, owner of the Motorcycle Museum in Meredith, said the ashes come from the chimney of the Mayhew Funeral Home.
"To be thinking of wiping up someone's human remains, it's just disgusting," said Leslyee Frederick, Doug's wife. The owner of the crematorium, however, said "We have received no indication of violations of any law or regulation."
The mother of a Boston firefighter was forced to jump from her burning home in the city's Dorchester neighborhood on Wednesday.
Her son rushed to her house as soon as he heard the call but only arrived after Regina Robinson was safely on the ground, thanks to a man doing a gutter estimate at a neighbor's home who spotted the flames pouring from her home and hearing her frantic screams.
Robinson said she was scared. Black smoke was filling her hallway, and "there was no other way but to go out that window."
Robinson jumped to the ground from a landing right below the window.
Former U.S. Sen. Bob Bennett, of Utah, who shied away from the spotlight but earned a reputation as someone who knew how to get things done in Washington, has died. He was 82.
Bennett assistant Tara Tanner said he died Wednesday from complications of pancreatic cancer and a recent stroke.
The Republican was first elected in 1992 and was widely seen at home as politically moderate, which at times put him at odds with Utah's highly conservative Republican base. His middle-of-the-road reputation led to his ouster in 2010 at the state convention by delegates fueled by tea party anger.
Sporadic violence persisted in Aleppo on Wednesday as U.S. officials announced an agreement had been reached with Russia to extend Syria's fragile cease-fire to the deeply contested northern city. The Syrian military said the truce would last only 48 hours.
Restoration of a partial truce would bring relief to residents on both sides of Syria's largest city after two weeks of relentless violence that has killed nearly 300 people, destroyed hospitals and brought it to the brink of humanitarian disaster.
It was not immediately clear whether the new effort will be observed or for how long. The U.S. and Russia finalized a nationwide cease-fire in late February, but have struggled to make it stick.
An Army captain sued President Barack Obama on Wednesday, alleging he doesn't have the proper congressional authority to wage war against Islamic State militants in Iraq and Syria.
Capt. Nathan Michael Smith filed the suit in U.S. District Court in Washington as the president is deploying more special operations forces to the region — and a day after a Navy SEAL was killed in combat in Iraq, the third since a U.S.-led coalition launched its campaign against the Islamic State in the summer of 2014.
The White House did not comment on the lawsuit.
Carla Schaffer / AAAS
A new type of robot can perform tricky surgery as well as — and in some cases better than — human surgeons, NBC News reported.
Researchers with Children’s National Medical Center in Washington said the new robot — called Smart Tissue Autonomous Robot, or STAR — could be operated with minimal human supervision. That means it frees up surgeons for work that requires more thought.
The team, led by Dr. Peter Kim of Children's National Medical Center in Washington, compared the robot to some existing systems and to human surgeons. It was reported to be slow, but accurate, and managed to sew together two ends of a tiny pig intestine.
Get More at NBC News
ISIS is looking to increase revenue from taxation, smuggling antiquities "and potentially kidnap for ransom" after losing some territory and oil revenue following the destruction of significant oil facilities, the chair of the U.N. committee monitoring sanctions against the militant group and al-Qaida said Wednesday.
New Zealand's U.N. Ambassador Gerard van Bohemen told the U.N. Security Council that the Islamic State group is not short of arms or fighters.
While recent reports indicate that the flow of recruits is slowing, he said, "estimates suggest that upwards of 30,000 foreign terrorist fighters have traveled to Iraq and Syria to date."
NBC 5 News
Former Texas A&M and Cleveland Browns quarterback Johnny Manziel made his first court appearance in Dallas on Thursday after his indictment in a domestic violence case involving an ex-girlfriend.
Manziel, who is from Kerrville, posted bond Wednesday in Highland Park after being booked on a misdemeanor assault family violence charge, his attorney said. In court Thursday, a judge ordered Manziel to have no contact with the alleged victim and barred him from possessing firearms.
The athlete was indicted last month by a Dallas County grand jury in connection with an alleged Jan. 29 incident involving then-girlfriend Colleen Crowley.
Infecting mosquitoes with a strain of bacteria reduced their ability to transmit the Zika virus, according to Brazilian researchers, NBC News reported.
Mosquitoes infected with the Wolbachia bacteria have been released in several countries including Australia, Brazil, Indonesia and Vietnam to help control dengue — and new findings are showing success with Zika. This raises hopes that it might block transmission of the virus.
The new study, by researchers at Brazil's Oswaldo Cruz Foundation and published in Cell Host & Microbe, takes advantage of the naturally occurring strain of Wolbachia, which live in insect cells and are found in 60 percent of common insects. The method involves inserting the bacteria into mosquito eggs, which pass the bacteria along to their offspring.
Corbis via Getty Images
Donald Trump's last Republican foe, Ohio Gov. John Kasich, ended his quixotic presidential campaign Wednesday, cementing Trump's remarkable triumph as his party's presumptive nominee and launching him toward a likely fall battle with Hillary Clinton.
Some reluctant Republicans began to rally around Trump, but others agonized over their party's future.