Two air ambulances were called Tuesday to transport two victims of a crash outside of Ramona.
Cal Fire said two people suffered major injuries in a multi-vehicle crash on Dye Road near Lansdown Lane and State Route 67 just after 4:30 p.m.
CHP Officer Ken Paredes said a Mercedez sedan was likely speeding headed westbound on Dye Road when it sideswiped a Subaru and collided head-on with a Toyota Tacoma truck.
Sky Ranger 7 showed firefighters rescue the driver of the truck, a 74-year-old man. Crews used saws to remove the top of the truck.
The driver was life-flighted to Scripps Mercy Hospital with major injuries, officials said.
The Mercedez was missing its entire front end after the crash and its engine block was left in the roadway. Its driver, a 56-year-old Poway man, was also airlifted to Palomar Medical Center with serious injuries.
The driver of the Subaru, a 53-year-old woman, was taken by ambulance to Pomerado Hospital with minor injuries.
Dye Road was shut down between SR-67 and San Vicente Road, Cal Fire said.