A pedestrian was fatally struck near the F Street off-ramp to State Route 94, California Highway Patrol said.
The victim was hit just before 10 p.m. Monday right before the Interstate 5 junction near downtown.
Harbor Police Officers were the first to report someone walking on the freeway.
About a minute later a woman called CHP to say she had hit the pedestrian.
The victim is a man and a known transient in the area officials confirmed. There was no other information on his identity.
The driver has no reported injuries.
The investigation is ongoing.