Caltrans crews were expected to conduct a weekend closure of all lanes of southbound state Route 125 starting Friday night.
The closure will start at 9 p.m. Friday until 4 a.m. Monday for a concrete slab replacement.
Drivers will be detoured.
Southbound SR-125 motorists south of state Route 94 will exit using the Jamacha Road off-ramp and reenter the freeway using the on-ramp, a statement from the state Department of Transportation said.
Get San Diego local news, weather forecasts, sports and lifestyle stories to your inbox. Sign up for NBC San Diego newsletters.
Motorists traveling southbound on SR-125 before SR-94 will be detoured to westbound SR-94 to avoid the closure.
Westbound SR-94 traffic can connect to SR-125 via Interstate 805 south to state Route 54 east to SR-125 north.
Local
The maintenance work schedule is subject to change due to weather, traffic incidents, or other maintenance considerations, the Caltrans statement read.