More than 1,700 people are without power in Uptown, according to San Diego Gas & Electric.
Areas affected by the outage include Old Town, Mission Hills and Hillcrest.
Power went out around 11:45 a.m. and SDG&E workers are assessing the damage. They are unsure what caused the incident.
This is the third day of outages in the area. Power went out in parts of Hillcrest Tuesday night, and workers shut down parts of Washington Street yesterday to work on repairing the circuit.
Estimated time of restoration is 2:15 p.m.