A fatal crash at one point closed down all lanes of traffic on southbound Interstate 15 just north of State Route 76 around 9:52 p.m. Monday, according to Caltrans San Diego.
North County Fire Protection District responded to the incident and urged drivers to expect delays and use alternate routes, the agency wrote on Twitter.
All lanes were reopened by 12:30 a.m. Tuesday, Caltrans announced.
Details on the deceased, such as their age and gender, were not immediately available.
Get San Diego local news, weather forecasts, sports and lifestyle stories to your inbox. Sign up for NBC San Diego newsletters.