"I'm playing with a little more confidence each game," Greene said. "I'm feeling better. I feel like I don't even think about my knee, like I've never been injured."
Maya Moore led UConn with 21 points, 17 in the first half. The sophomore also had nine rebounds and six assists while playing just 25 minutes. Tina Charles added 17 points for the Huskies, who now have won 26 consecutive home games and 89 straight games over unranked opponents.
Jene Morris scored 17 points and had five rebounds to lead San Diego State (2-1).
Greene, who went five-for-five in the Huskies' season-opening win over Georgia Tech, didn't miss against the Aztecs until a 3-pointer fell off the rim with 16:24 to play.
"Kalana did a great job of being a leader tonight," Moore said. "It makes us feel invincible knowing that when Kalana's on, what's the other team going to do? It just gives us a whole lot of confidence."
Renee Montgomery also had 13 points for Connecticut and freshman Tiffany Hayes added 11, hitting 3 of 4 from 3-point range.
The Huskies, who hit 64 percent of their shots, made nine of their first 12, and opened on a 12-2 run. The Aztecs missed their first five shots and hit just 37 percent from the field.
"We have this saying that hard work beats talent when talent won't work hard, so when you put great talent that works hard against people who weren't working hard, I'm really disappointed," Aztec coach Beth Burns said.
San Diego State got as close as 28-18 before a pair of buckets by Greene, the second one coming on a no-look pass from Caroline Doty. That started a 10-0 UConn run.
UConn shot over 65 percent from the floor in the first half and led 56-27 at intermission. The Huskies opened the second half with a 14-0 run, allowing coach Geno Auriemma to go deep into his bench early.
When Charles passed over a double team and found Meghan Gardler underneath with just under 11 minutes to go, it was 85-36. Twelve Huskies played, and 11 of them scored.
"We were in a real good rhythm offensively," Auriemma said. "We could score almost every time down the floor, and much of that had to do with the fact that we were intent on being aggressive and making the next play."
San Diego State, which opened its season with wins over Northwestern State and Long Beach State, was making its first trip to the East Coast since playing at Penn State and Duquesne in 1997. The Aztecs travel back to San Diego for a game Tuesday, and then head to Hawaii. That's over 10,200 miles in eight days.