Pau Gasol tallied 24 points and 13 rebounds for the Lakers, who moved to an NBA-best 44-10 record. Lamar Odom ended with 22 points and seven boards for Los Angeles, which beat Golden State for a fourth straight time.
Trevor Ariza scored 17, Josh Powell 16 and Derek Fisher 12 for the Lakers, who trailed most of the game before taking command late in the final quarter.
Bryant, coming off a lackluster 10-point performance in a home win over the Hawks on Tuesday, shot 9-of-22 from the field and missed two of his 12 foul shots. He also had two scintillating blocks.
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Stephen Jackson totaled 24 points, six boards and nine assists for the Warriors, who had a three-game win streak broken. Corey Maggette had 24 points off the bench before fouling out, and Jamal Crawford scored 23. Anthony Randolph played a spirited game with 14 points and 12 assists in defeat.