The Toreros are undefeated at home in the La Mont Smith era.
Senior Duda Sanadze tallied a game-high 21 points to lead the Toreros to victory against scrappy Bethesda.
USD has now won back-to-back contests after an 0-5 start.
Junior Brett Bailey scored 9 points Wednesday night including a couple of and-1’s that sparked the Toreros.
USD trailed by 3 at intermission despite going just 1-14 from behind the arc in the first half.
But an early 8-0 run in the second half helped them grab the lead from the Flames.
USD faces cross-town rival San Diego State Sunday at 2 p.m. in the first college basketball game played at Petco Park.