A Sig alert was issued for three lanes of Interstate 805 in Chula Vista after a crash involving a motorcycle and pickup truck, officials said.
The crash happened at approximately 4:40 p.m. near Orange Avenue, California Highway Patrol officials said.
Three lanes are blocked as crews work to clean up the road.
The extent of the injuries to those involved is unknown.
A Sig alert was put in place as crews worked to clean up.
There was no other information immediately available.