Three people were injured when two cars collided Tuesday along State Route 78 just west of the junction with State Route 79.
The head-on crash happened just before 8 a.m. near Dudley's Bakery.
A Nissan Altima was traveling eastbound on SR-78 when it crossed the double yellow line, according to California Highway Patrol officers.
The Altima crashed head-on into a BMW traveling westbound.
The BMW burst into flames, according to the CHP.
A 27-year-old man from Ridgecrest, California was driving the BMW. He was airlifted to UCSD Medical center with what was described by CHP as life-threatening injuries.
His passenger, a 20-year-old Julian woman, was driven to Sharp Memorial Hospital.
The driver of the Altima, described by CHP as a 45-year-old Julian woman was also injured and taken to Sharp Memorial Hospital.
One person was trapped in a fiery crash along State Route 78 in Santa Ysabel.
California Highway Patrol officers and Cal Fire crews responded to find a major injury accident with one car on fire.
SR-78 was closed in both directions and a medical helicopter was requested.
As of 9:30 a.m., there was one-way traffic in the area.
No other information was immediately available.