A car and pedestrian in a wheelchair collided, El Cajon Public Information Officer Monica Zech said.
The incident happened around 4:30 p.m. Monday near Greenfield and Linalda Drive.
The person in the wheelchair was injured and taken to Sharp Memorial Hospital, El Cajon Police said. The victim was hit by a white Toyota Tundra, and the driver has not been identified.
Cal Fire and San Diego Sheriff's deputies were on scene.
No other injuries were reported.
No further information was immediately available.