The Padres traded for a closer on Thursday. Unfortunately he wasn't available for their ninth inning against Arizona.
Clinging onto a 2-0 lead in the final frame rookie reliever Robert Suarez walked two batters and hit a third to load the bases.
Bob Melvin replaced Suarez with Craig Stammen, who let one run come across on a wild pitch before serving up a three-run walk off homer to Seth Beer.
The Padres dropped their 2022 season opener 4-2.
The disappointing finish spoiled a great night for Yu Darvish. Just two days shy of the first anniversary of Joe Musgrove's no-hitter, Darvish flirted with history. Darvish made it through six innings without allowing a hit but was pulled with his pitch count at 92 with nine outs still to go.
Darvish kept Arizona's bats completely in check, but finished with a modest three strikeouts while allowing four walks.
Darvish is the first National League pitcher in the modern era to get through six frames without allowing a hit on Opening Day, according to Stats Perform.
Hopes of a combined no-no vanished in the seventh inning when Pavin Smith recorded a leadoff single off of Tim Hill.
The Padres showed a ton of patience at the plate in their 2022 debut. They made sure Madison Bumgarner didn't pitch past the third thanks to a series of long at-bats.
In Bumgarner's final inning, Ha-Seong Kim drew an 11-pitch walk. Manny Machado also got a free pass, followed by a nine-pitch walk from Jake Cronenworth. After falling behind 0-2, Luke Voit watched four straight balls go by to push across the first run of the season.
One inning later Trent Grisham singled on the ninth pitch he faced. That sent Kim to third, but he wasn't there for long - an Austin Nola single sent him across and put the Friars ahead 2-0.
San Diego's bullpen held the lead until the final frame when the D-Backs loaded the bases with nobody out. Lefty Taylor Rogers, who was acquired in a trade with Minnesota Thursday morning, will take over closing duties.