A car drove off the side of an Interstate 5 overpass in Golden Hill, crashing below near the intersection of 19th Street and B Street, the California Highway Patrol (CHP) confirmed.
The incident happened at approximately 9:19 p.m., according to CHP.
CHP says the driver was transported to the hospital with major injuries. It is unknown what caused the vehicle, a Chevy Corvette, according to CHP, to go off the freeway.
The I-5 onramp at B Street has reopened, as have surrounding roadways.
Check back for updates on this breaking news.