A rollover crash blocked three lanes of traffic on State Route 163 and trapped two people inside, according to California Highway Patrol.
The vehicle toppled over on northbound SR-163 near Interstate 15 at 3:50 p.m.
Firefighters and CHP officers worked to free two people caught inside the badly damaged car.
The patients were taken to nearby hospitals. Their conditions are unknown.
Traffic was backed up for miles in the area.