Strasburgh went five innings, struck out eight batters and gave up only one earned run. He allowed 4 hits and a couple walks, but was impressive, throwing in the high 90's.
He got the win, 6 to 4 over the Altoona Curve.
Strasburg was sent to the minor leagues in March by the Washington Nationals, who told baseball's top pitching prospect he needed to slow down his delivery from the stretch in order to speed up his arrival in the majors.
"I'm not a believer that a player can come from amateur baseball and step right into the major leagues,'' Nationals general manager Mike Rizzo said. "I've seen terrific prospects attempt it and the failure rate is too great. This is a prized asset.''
The Nationals optioned the 21-year-old Strasburg, the top overall pick in June's draft, to Double-A Harrisburg.
"If they tell me what to do, I'm going to do it,'' said Strasburg who signed a $15.1 million contract in August. "Sometimes it won't make sense, but more times than not, it's going to work out in the long run. I trust what they're doing with me.''
When the SDSU alum will make his big league debut remains to be seen. The Nationals led the majors with 103 losses last season.