The San Diego Padres played the Texas Rangers in their 36th and final exhibition game of the year.
Chris Denorfia hit a pair of homers, but the Padres lost 5-2 when Leury Garcia lined a three-run homer over the 285-foot sign in the Alamodome.
The Rangers swept both games played in the Alamodome, which is designed primarily for football and special events such as the NCAA Final Four but had not hosted baseball until this weekend.
"That's a good call, to say it's an Alamodome home run," Padres manager Bud Black said. "But when guys give you a high-five after you circled the bases in any ballpark, it's a good feeling."
The Padres finished Spring Training with a 16-20 record.
Texas opens the regular season Sunday night in Houston against a new AL West rival in the Astros. San Diego travels to New York to face the Mets on Monday.