Aztecs star running back Ronnie Hillman spent much of the second half on the sidelines with a hip injury, but it didn't slow the Aztecs (5-2, 2-1 Mountain West). He finished the evening with 64 yards in 18 carries, including a touchdown.
New Mexico (0-7, 0-3) scored first when James Aho kicked a 46-yard field goal, but Hillman's touchdown gave the Aztecs the lead for good at 7-3.
Sampson caught a 40-yard touchdown pass from Ryan Lindley on the final play of the first half -- outjumping two New Mexico defenders in the end zone to give San Diego State a 17-6 lead. The duo combined on a 32-yard score in the third quarter.
Sampson finished with seven receptions for 127 yards. Lindley went 18-for-35 for 249 yards.
The Lobos have lost 22 of their last 23 games. They finished with 308 yards of total offense and didn't convert a third down until midway through the fourth quarter, misfiring on their first 11 attempts.
New Mexico tight end Lucas Reed had 100 yards receiving and two touchdowns.