A Sig Alert was issued early Tuesday along northbound Interstate 5 just south of Carmel Valley.
A truck carrying sand cement overturned in the HOV lanes just after 6 a.m.
California Highway Patrol officers said approximately 6 to 8 yards of sand cement spilled in the lanes.
The driver was evaluated by emergency medical personnel.
No other cars were involved.
All lanes of northbound I-5 were reopened as of 10 a.m.