Aerial views of the crash in Valley Center show multiple firefighters and medics at the scene.
A person died after a car struck a minivan in Valley Center on Monday morning, according to California Highway Patrol.
The incident happened just before noon at Valley Center Road and Cole Grade Road. Officials shut down the road while they cleared the scene.
A Toyota Camry hit a Chrysler minivan head-on when the driver crossed the double yellow lines and struck the minivan, according to Officer Jim Bettencourt. The driver of the Toyota died at the scene.
The victims inside the minivan include a 38-year-old man and his 40-year-old wife and 7-year-old twin boys. Helicopters transported the adults to Palomar Hospital and the children Rady Children's Hospital.
Alcohol or drugs are not suspected in the collision and officials are investigating the incident.